Genetic regressive trajectories in colorectal cancer: A new hallmark of oligo-metastatic disease?

Genetic regressive trajectories in colorectal cancer: A new hallmark of oligo-metastatic disease?

Colorectal cancer (CRC) originates as consequence of multiple genetic alterations. Some of the involved genes have been extensively studied (APC, TP53, KRAS, SMAD4, PIK3CA, MMR genes) in highly heterogeneous and poly-metastatic cohorts. However, about 10% of metastatic CRC patients presents with an...

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Bibliographic Details
Main Authors: Alessandro Ottaiano, Mariachiara Santorsola, Michele Caraglia, Luisa Circelli, Valerio Gigantino, Gerardo Botti, Guglielmo Nasti
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Translational Oncology
Subjects:
Oligo-metastases
Colorectal cancer
Genetics
NGS
Mutations
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001236

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http://www.sciencedirect.com/science/article/pii/S1936523321001236

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