Clonal evolution and progression of 20-methylcholanthrene-induced squamous cell carcinoma of mouse epidermis as revealed by DNA instability and other malignancy markers

We examined the clonal evolution of skin malignant lesions by repeated topical applications of 20- methylcholanthrene (20-MC) to the skin, which induces hyperplastic epidermis, papillomatous lesion and invasive carcinoma in mice. The lesions were examined histologically and immunohistochemically wit...

Full description

Bibliographic Details
Main Authors: K Hirai, M Kumakiri, K Ueda, Y Imamura, S Noriki, Y Nishi, H Kato, M Fukuda
Format: Article
Language:English
Published: PAGEPress Publications 2009-12-01
Series:European Journal of Histochemistry
Online Access:https://www.ejh.it/index.php/ejh/article/view/1641