Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae

Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae

The precise impact of the somatotrope axis upon the immune system is still highly debated. We have previously shown that mice with generalized ablation of growth hormone (GH) releasing hormone (GHRH) gene (Ghrh−/−) have normal thymus and T-cell development, but present a marked spleen atrophy and B-...

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Bibliographic Details
Main Authors: Khalil Farhat, Gwennaëlle Bodart, Chantal Charlet-Renard, Christophe J. Desmet, Michel Moutschen, Yves Beguin, Frédéric Baron, Pierrette Melin, Pascale Quatresooz, Anne-Simone Parent, Daniel Desmecht, Jean-Claude Sirard, Roberto Salvatori, Henri Martens, Vincent G. Geenen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
somatotrope axis
GHRH
GH
S. pneumonia
thymo-independent antigen
spleen
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02175/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02175/full

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