The Post-translational Modifications of Smurf2 in TGF-β Signaling

The Post-translational Modifications of Smurf2 in TGF-β Signaling

Smad ubiquitin regulatory factor 2 (Smurf2), an essential negative regulator of TGF-β signaling, ubiquitinates TGF-β receptors (TβRs) and Smad proteins, inducing their proteasomal degradation. Smurf2 plays crucial roles in regulating TGF-β signaling and maintaining normal cellular functions and tiss...

Full description

Bibliographic Details
Main Authors: Yangjinming Bai, Ying Ying
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
post-translational modifications
Smurf2
SUMOylation
ubiquitylation
neddylation
phosphorylation
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00128/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00128/full

Similar Items