DNA Sliding Clamps as Therapeutic Targets

DNA Sliding Clamps as Therapeutic Targets

Chromosomal DNA replication is achieved by an assembly of multi-protein complexes at the replication fork. DNA sliding clamps play an important role in this assembly and are essential for cell viability. Inhibitors of bacterial (β-clamp) and eukaryal DNA clamps, proliferating cell nuclear antigen (P...

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Bibliographic Details
Main Authors: Amanda S. Altieri, Zvi Kelman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
β-clamp
DNA clamp
DNA sliding clamp
proliferating cell nuclear antigen
PCNA
therapeutic
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2018.00087/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2018.00087/full

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