In vivo analysis of torsadogenic potential of an antipsychotic drug paliperidone using the acute atrioventricular block rabbit as a proarrhythmia model

In vivo analysis of torsadogenic potential of an antipsychotic drug paliperidone using the acute atrioventricular block rabbit as a proarrhythmia model

We assessed electrophysiological effects of an atypical antipsychotic drug paliperidone in acute atrioventricular block rabbits. Intravenous administration of paliperidone at a clinically relevant dose (0.06 mg/kg) hardly affected the QT interval or monophasic action potential (MAP) duration, and th...

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Bibliographic Details
Main Authors: Mihoko Hagiwara, Ryuichi Kambayashi, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Journal of Pharmacological Sciences
Subjects:
Paliperidone
QT prolongation
Torsades de pointes
Atrioventricular block
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316300536

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