In vivo analysis of torsadogenic potential of an antipsychotic drug paliperidone using the acute atrioventricular block rabbit as a proarrhythmia model

by Mihoko Hagiwara, Ryuichi Kambayashi, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara
Published 2016-09-01

Electropharmacological profile of an atrial-selective sodium channel blocker acehytisine assessed in the isoflurane-anesthetized guinea-pig model

by Xin Cao, Yoshinobu Nagasawa, Chengshun Zhang, Hanxiao Zhang, Megumi Aimoto, Akira Takahara
Published 2019-12-01

Sensitivity of inhalation anesthetics isoflurane and sevoflurane for the drug-induced QT-interval prolongation in guinea pigs

by Yoshinobu Nagasawa, Kaori Sakai, Rui Kurimoto, Satoshi Kawakami, Megumi Aimoto, Akira Takahara
Published 2020-05-01

Acehytisine suppresses atrial fibrillation in rats with dilated atria caused by chronic volume overload

by Xin Cao, Yoshinobu Nagasawa, Chengshun Zhang, Hanxiao Zhang, Megumi Aimoto, Akira Takahara
Published 2020-01-01

Influence of chronic volume overload-induced atrial remodeling on electrophysiological responses to cholinergic receptor stimulation in the isolated rat atria

by Xin Cao, Megumi Aimoto, Marie Fukumoto, Yoshinobu Nagasawa, Hikaru Tanaka, Akira Takahara
Published 2018-02-01

Torsadogenic potential of a novel remyelinating drug clemastine for multiple sclerosis assessed in the rabbit proarrhythmia model

by Satoshi Kawakami, Yoshinobu Nagasawa, Mihoko Hagiwara-Nagasawa, Kensuke Omura, Megumi Aimoto, Akira Takahara
Published 2020-11-01

Selectivity of Ca2+ channel blockers for dilator actions on the isolated lower esophageal sphincter and aorta from rats

by Akira Takahara, Shuhei Nozaki, Akane Ishiguro, Kaori Okamura, Xin Cao, Megumi Aimoto, Yoshinobu Nagasawa
Published 2018-05-01

Angiotensin II acutely increases arterial stiffness as monitored by cardio-ankle vascular index (CAVI) in anesthetized rabbits

by Kiyoshi Sakuma, Akira Shimoda, Hiroaki Shiratori, Tetsuya Komatsu, Kento Watanabe, Tatsuo Chiba, Megumi Aimoto, Yoshinobu Nagasawa, Yuichi Hori, Kohji Shirai, Akira Takahara
Published 2019-06-01

Physiological role of nitric oxide for regulation of arterial stiffness in anesthetized rabbits

by Tatsuo Chiba, Kiyoshi Sakuma, Tetsuya Komatsu, Xin Cao, Megumi Aimoto, Yoshinobu Nagasawa, Kazuhiro Shimizu, Mao Takahashi, Yuichi Hori, Kohji Shirai, Akira Takahara
Published 2019-01-01

Manifestation of automaticity in the pulmonary-vein myocardium of rats with abdominal aorto-venocaval shunt

by Shogo Hamaguchi, Yayoi Tsuneoka, Ayumi Tanaka, Masahiko Irie, Masato Tsuruta, Takahiro Nakayama, Iyuki Namekata, Mizuki Nada, Megumi Aimoto, Akira Takahara, Hikaru Tanaka
Published 2015-08-01