A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease RatsSummary

A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease RatsSummary

Background & Aims: In Wilson disease, ATP7B mutations impair copper excretion into bile. Hepatic copper accumulation may induce mild to moderate chronic liver damage or even acute liver failure. Etiologic factors for this heterogeneous phenotype remain enigmatic. Liver steatosis is a frequent fi...

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Bibliographic Details
Main Authors: Claudia Einer, Christin Leitzinger, Josef Lichtmannegger, Carola Eberhagen, Tamara Rieder, Sabine Borchard, Ralf Wimmer, Gerald Denk, Bastian Popper, Frauke Neff, Elena V. Polishchuk, Roman S. Polishchuk, Stefanie M. Hauck, Christine von Toerne, Jennifer-Christin Müller, Uwe Karst, Bipin S. Baral, Alan A. DiSpirito, Andreas E. Kremer, Jeremy Semrau, Karl Heinz Weiss, Simon Hohenester, Hans Zischka
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X18301802

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http://www.sciencedirect.com/science/article/pii/S2352345X18301802

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