Acute toxicity of cyanide in aerobic respiration: Theoretical and experimental support for murburn explanation

Acute toxicity of cyanide in aerobic respiration: Theoretical and experimental support for murburn explanation

The inefficiency of cyanide/HCN (CN) binding with heme proteins (under physiological regimes) is demonstrated with an assessment of thermodynamics, kinetics, and inhibition constants. The acute onset of toxicity and CN’s mg/Kg LD50 (μM lethal concentration) suggests that the classical hemeFe binding...

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Bibliographic Details
Main Authors: Manoj Kelath Murali, Ramasamy Surjith, Parashar Abhinav, Gideon Daniel Andrew, Soman Vidhu, Jacob Vivian David, Pakshirajan Kannan
Format: Article
Language:English
Published: De Gruyter 2020-03-01
Series:Biomolecular Concepts
Subjects:
cyanide-poisoning
murburn concept
aerobic respiration
atp-synthesis
hemoglobin
cytochrome oxidase
mitochondria
diffusible reactive oxygen species (dros)
Online Access:https://doi.org/10.1515/bmc-2020-0004

Internet

https://doi.org/10.1515/bmc-2020-0004

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