Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival

B-cell lymphoma 2 protein (BCL-2) is one of the more widely investigated anti-apoptotic protein in mammals, and its levels are critical for protecting from programmed cell death. We report here that the cellular content of BCL-2 is regulated at post-translational level along the autophagy/lysosome p...

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Bibliographic Details
Main Authors: Laura Lossi, Graziana Gambino, Chiara Salio, Adalberto Merighi
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2010.82