The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of Vibrio cholerae Chromosome 2

Replication of Vibrio cholerae chromosome 2 (Chr2) depends on molecular chaperone DnaK to facilitate binding of the initiator (RctB) to the replication origin. The binding occurs at two kinds of site, 12-mers and 39-mers, which promote and inhibit replication, respectively. Here we show that DnaK em...

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Bibliographic Details
Main Authors: Jyoti K. Jha, Mi Li, Rodolfo Ghirlando, Lisa M. Miller Jenkins, Alexander Wlodawer, Dhruba Chattoraj, Gary M. Dunny
Format: Article
Language:English
Published: American Society for Microbiology 2017-04-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/2/e00427-17