Predictive role of multiple gene alterations in response to cetuximab in metastatic colorectal cancer: A single center study

Predictive role of multiple gene alterations in response to cetuximab in metastatic colorectal cancer: A single center study

<p>Abstract</p> <p>Background</p> <p><it>KRAS</it> mutations negatively affect outcome after treatment with cetuximab in metastatic colorectal cancer (mCRC) patients. As only 20% of <it>KRAS</it> wild type (WT) patients respond to cetuximab it is...

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Bibliographic Details
Main Authors: Ulivi Paola, Capelli Laura, Valgiusti Martina, Zoli Wainer, Scarpi Emanuela, Chiadini Elisa, Rosetti Paola, Bravaccini Sara, Calistri Daniele, Saragoni Luca, Gardini Andrea, Ragazzini Angela, Frassineti Giovanni, Amadori Dino, Passardi Alessandro
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Journal of Translational Medicine
Subjects:
Metastatic colorectal cancer
Cetuximab
KRAS
BRAF
PIK3CA
PTEN
Online Access:http://www.translational-medicine.com/content/10/1/87

Internet

http://www.translational-medicine.com/content/10/1/87

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