Sir4 Deficiency Reverses Cell Senescence by Sub-Telomere Recombination

Sir4 Deficiency Reverses Cell Senescence by Sub-Telomere Recombination

Telomere shortening results in cellular senescence and the regulatory mechanisms remain unclear. Here, we report that the sub-telomere regions facilitate telomere lengthening by homologous recombination, thereby attenuating senescence in yeast <i>Saccharomyces cerevisiae</i>. The telomer...

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Bibliographic Details
Main Authors: Jun Liu, Xiaojing Hong, Lihui Wang, Chao-Ya Liang, Jun-Ping Liu
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
cell senescence
senescence regulation
sub-telomeres
telomere binding protein
Sir4
Rif1
Online Access:https://www.mdpi.com/2073-4409/10/4/778

Internet

https://www.mdpi.com/2073-4409/10/4/778

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