Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway

Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway

While angiotensin II (ang II) has been implicated in the pathogenesis of cardiac cachexia (CC), the molecules that mediate ang II's wasting effect have not been identified. It is known TNF-α level is increased in patients with CC, and TNF-α release is triggered by ang II. We therefore hypothesi...

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Bibliographic Details
Main Authors: Congcong Shen, Jin Zhou, Xiaoxiao Wang, Xi-Yong Yu, Chun Liang, Bin Liu, Xiangbin Pan, Qiong Zhao, Jenny Lee Song, Jiajun Wang, Meiyu Bao, Chaofan Wu, Yangxin Li, Yao-Hua Song
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:EBioMedicine
Subjects:
Cardiac cachexia
Heart failure
TNF-α
Angiotensin II
Ch25h
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417300440

Internet

http://www.sciencedirect.com/science/article/pii/S2352396417300440

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