Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells

Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells

Pyroptosis is a form of programmed cell death, in which gasdermin E (GSDME) plays an important role in cancer cells, which can be induced by activated caspase-3 on apoptotic stimulation. Triclabendazole is a new type of imidazole in fluke resistance and has been approved by the FDA for the treatment...

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Bibliographic Details
Main Authors: Liang Yan, Yi Liu, Xue-feng Ma, Dan Hou, Yu-hui Zhang, Yong Sun, Shan-shan Shi, Tim Forouzanfar, Hai-yan Lin, Jun Fan, Gang Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
triclabendazole
pyroptosis
gasdermin E
caspase-3
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.670081/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.670081/full

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