Temporal Control of the Helicobacter pylori Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis

Temporal Control of the Helicobacter pylori Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis

The “hit-and-run model” of carcinogenesis proposes that an infectious agent triggers carcinogenesis during initial stages of infection and that the ongoing presence of the infectious agent is not required for development of cancer. H. pylori infection and actions of CagA (an effector protein designa...

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Bibliographic Details
Main Authors: Aung Soe Lin, Mark S. McClain, Amber C. Beckett, Rhonda R. Caston, M. Lorena Harvey, Beverly R. E. A. Dixon, Anne M. Campbell, Jennifer H. B. Shuman, Neha Sawhney, Alberto G. Delgado, John T. Loh, M. Blanca Piazuelo, Holly M. Scott Algood, Timothy L. Cover
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mBio
Subjects:
helicobacter pylori
type iv secretion system
gastric cancer
carcinogenesis
animal model
hit-and-run hypothesis
animal models
gene regulation
Online Access:https://doi.org/10.1128/mBio.01296-20

Internet

https://doi.org/10.1128/mBio.01296-20

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