Phosphate Brain Energy Metabolism and Cognition in Alzheimer’s Disease: A Spectroscopy Study Using Whole-Brain Volume-Coil 31Phosphorus Magnetic Resonance Spectroscopy at 7Tesla

Phosphate Brain Energy Metabolism and Cognition in Alzheimer’s Disease: A Spectroscopy Study Using Whole-Brain Volume-Coil 31Phosphorus Magnetic Resonance Spectroscopy at 7Tesla

IntroductionMitochondrial dysfunction is a neurometabolic hallmark signaling abnormal brain energy metabolism (BEM) targeted as a potential early marker of Alzheimer’s disease (AD). Advanced imaging technologies, such as 31phosphorus magnetic resonance spectroscopy (31P MRS) at ultra-high-field (UHF...

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Bibliographic Details
Main Authors: Namrata Das, Jimin Ren, Jeffrey Spence, Sandra Bond Chapman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Neuroscience
Subjects:
phosphate brain energy metabolism
Alzheimer’s disease
amnestic mild cognitive impairment
31phosphorus magnetic resonance spectroscopy
adenosine triphosphate
mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.641739/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.641739/full

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