NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury

NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury

Inflammation in the absence of infection (sterile inflammation) contributes to acute injury and chronic disease. Cerebral ischaemia is a devastating condition in which the primary injury is caused by reduced blood supply and is therefore sterile. The cytokine interleukin-1β (IL-1β) is a key contribu...

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Bibliographic Details
Main Authors: Catherine Diane Savage, Gloria eLopez-Castejon, Adam eDenes, David eBrough
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-09-01
Series:Frontiers in Immunology
Subjects:
Inflammation
Interleukin-1
priming
caspase-1
cerebral ischaemia
NLRP3-inflammasome
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00288/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00288/full

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