Vitamin D Signaling Through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models

Vitamin D Signaling Through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models

Metabolic syndrome (MetS), characterized as obesity, insulin resistance, and non-alcoholic fatty liver diseases (NAFLD)，is associated with vitamin D insufficiency/deficiency in epidemiological studies, while the underlying mechanism is poorly addressed. On the other hand, disorder of gut microbiota,...

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Bibliographic Details
Main Authors: Danmei Su, Airu Zhu, Yuanyang Nie, Zishuo Chen, Pengfei Wu, Li Zhang, Mei Luo, Qun Sun, Linbi Cai, Yuchen Lai, Zhixiong Xiao, Zhongping Duan, Sujun Zheng, Guihui Wu, Richard Hu, Hidekazu Tsukamoto, Aurelia Lugea, Stephen J Pandol, Yuan-Ping Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Physiology
Subjects:
Defensins
Helicobacter
Mice
Vitamin D
metabolic syndrome
microbiome
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00498/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00498/full

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