Cardenolide-Induced Lysosomal Membrane Permeabilization Demonstrates Therapeutic Benefits in Experimental Human Non-Small Cell Lung Cancers

Cardenolide-Induced Lysosomal Membrane Permeabilization Demonstrates Therapeutic Benefits in Experimental Human Non-Small Cell Lung Cancers

Non-small cell lung cancers (NSCLCs) are the leading cause of cancer deaths in most developed countries. Targeting heat shock protein 70 (Hsp70) expression and function, together with the induction of lysosomal membrane permeabilization (LMP), could overcome the multiple anti-cell death mechanisms...

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Bibliographic Details
Main Authors: Tatjana Mijatovic, Véronique Mathieu, Jean-François Gaussin, Nancy De Néve, Fabrice Ribaucour, Eric Van Quaquebeke, Patrick Dumont, Francis Darro, Robert Kiss
Format: Article
Language:English
Published: Elsevier 2006-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
NSCLCs
cardenolides
antitumor agent
Hsp70
lysosomal membrane permeabilization
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800606

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http://www.sciencedirect.com/science/article/pii/S1476558606800606

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