TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection

TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection

The function of natural killer (NK) cell-derived interferon-γ (IFN-γ) expands to remove pathogens by increasing the ability of innate immune cells. Here, we identified the critical role of thioredoxin-interacting protein (TXNIP) in the production of IFN-γ in NK cells during bacterial infection. TXNI...

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Bibliographic Details
Main Authors: Dong Oh Kim, Jae-Eun Byun, Won Sam Kim, Mi Jeong Kim, Jung Ha Choi, Hanna Kim, Eunji Choi, Tae-Don Kim, Suk Ran Yoon, Ji-Yoon Noh, Young-Jun Park, Jungwoon Lee, Hee Jun Cho, Hee Gu Lee, Sang-Hyun Min, Inpyo Choi, Haiyoung Jung
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
NK cell
IFN-γ
TXNIP
TAK1
toll-like receptor (TLR)
bacterial infection
Online Access:https://www.mdpi.com/1422-0067/21/24/9499

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https://www.mdpi.com/1422-0067/21/24/9499

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