Rapid and reliable identification of insulin 2 gene mutation in Akita diabetic mice by a tetra-primer-ARMS-PCR method

Rapid and reliable identification of insulin 2 gene mutation in Akita diabetic mice by a tetra-primer-ARMS-PCR method

The Akita mouse, one of the most frequently used animal models for the study of diabetes mellitus and its complications, carries a heterozygous missense mutation (C96Y) in the insulin 2 (Ins2) gene that results in proinsulin misfolding in the endoplasmic reticulum (ER), ER stress, pancreatic beta ce...

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Bibliographic Details
Main Authors: Rambabu Undi, Hui-Ying Lim, Weidong Wang
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Heliyon
Subjects:
Endocrinology
Biochemistry
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018351247

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http://www.sciencedirect.com/science/article/pii/S2405844018351247

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