The synthesis of cis- and trans-3-(4-hydroxyphenyl)cyclobutanecarboxylic acids and the study of their derivatives as GPR-40 receptor ligands

The synthesis of cis- and trans-3-(4-hydroxyphenyl)cyclobutanecarboxylic acids and the study of their derivatives as GPR-40 receptor ligands

Aim. To synthesize cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarboxylic acid and evaluate the biological activity of their derivatives against GPR-40. Results and discussion. Cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarboxylic acid were synthesized. The derivatives of th...

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Bibliographic Details
Main Authors: I. O. Feskov, I. S. Kondratov, Yu. O. Kuchkovska, V. S. Naumchyk, O. V. Onopchenko, O. O. Grygorenko
Format: Article
Language:English
Published: National University of Pharmacy (Kharkiv, Ukraine) 2020-12-01
Series:Журнал органічної та фармацевтичної хімії
Subjects:
cyclobutane
gpr-40
ffar
agonist
diabetes mellitus
Online Access:http://ophcj.nuph.edu.ua/article/view/ophcj.20.210383

Internet

http://ophcj.nuph.edu.ua/article/view/ophcj.20.210383

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