Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation

Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation

Chronic inflammation in response to persistent exogenous stimuli or damage results in liver fibrosis, which subsequently progresses into malignant liver diseases with high morbidity and mortality. Ferulic acid (FA) is a phenolic acid widely isolated from abundant plants and exhibits multiple biologi...

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Bibliographic Details
Main Authors: Jianzhi Wu, Xiaoyong Xue, Guifang Fan, Yiqing Gu, Fei Zhou, Qi Zheng, Runping Liu, Yajing Li, Boning Ma, Shuo Li, Guangrui Huang, Lin Ma, Xiaojiaoyang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
ferulic acid
AMPK
PTP1B
oxidative stress
inflammation
liver fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.754976/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.754976/full

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