Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

Neutrophils normally fulfil their metabolic demands by glycolysis and have limited mitochondrial activity. Here the authors show that tumours promote neutrophils adapted to oxidative mitochondria metabolism that function in the glucose-restrained tumour microenvironment to promote tumour growth by m...

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Bibliographic Details
Main Authors: Christopher M. Rice, Luke C. Davies, Jeff J. Subleski, Nunziata Maio, Marieli Gonzalez-Cotto, Caroline Andrews, Nimit L. Patel, Erika M. Palmieri, Jonathan M. Weiss, Jung-Min Lee, Christina M. Annunziata, Tracey A. Rouault, Scott K. Durum, Daniel W. McVicar
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07505-2

Internet

https://doi.org/10.1038/s41467-018-07505-2

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