Purkinje Cell Degeneration and Motor Coordination Deficits in a New Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay

Purkinje Cell Degeneration and Motor Coordination Deficits in a New Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is an early-onset neurodegenerative disorder. In 2007, a novel locus, SAX2, which is located on chromosome 17p13 and contains 3 genes, ankyrin repeat and FYVE domain-containing 1 (ANKFY1), β-arrestin 2 (ARRB2) and kinesin family memb...

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Bibliographic Details
Main Authors: Man Ding, Chao Weng, Shanghua Fan, Qian Cao, Zuneng Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Ankfy1
ARSACS
neurodegenerative disease
NTFs
behavior
apoptosis
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00121/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00121/full

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