F8 Inversions at Xq28 Causing Hemophilia A Are Associated With Specific Methylation Changes: Implication for Molecular Epigenetic Diagnosis

F8 Inversions at Xq28 Causing Hemophilia A Are Associated With Specific Methylation Changes: Implication for Molecular Epigenetic Diagnosis

Diverse DNA structural variations (SVs) in human cancers and several other diseases are well documented. For genomic inversions in particular, the disease causing mechanism may not be clear, especially if the inversion border does not cross a coding sequence. Understanding about the molecular proces...

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Bibliographic Details
Main Authors: Muhammad Ahmer Jamil, Amit Sharma, Nicole Nuesgen, Behnaz Pezeshkpoor, André Heimbach, Anne Pavlova, Johannes Oldenburg, Osman El-Maarri
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Genetics
Subjects:
structural rearrangement
epigenetic
DNA methylation
inversion
hemophilia
molecular diagnosis
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00508/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00508/full

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