The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo.

The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo.

The slow-releasing hydrogen sulfide (H₂S) donor, GYY4137, caused concentration-dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS) but did not affect survival of normal human lung fibroblasts (IMR90, WI-38) as determined by trypan blue...

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Bibliographic Details
Main Authors: Zheng Wei Lee, Jianbiao Zhou, Chien-Shing Chen, Yujun Zhao, Choon-Hong Tan, Ling Li, Philip Keith Moore, Lih-Wen Deng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3119065?pdf=render

Internet

http://europepmc.org/articles/PMC3119065?pdf=render

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