Differential ketogenic diet-induced shift in CSF lipid/carbohydrate metabolome of pediatric epilepsy patients with optimal vs. no anticonvulsant response: a pilot study

Differential ketogenic diet-induced shift in CSF lipid/carbohydrate metabolome of pediatric epilepsy patients with optimal vs. no anticonvulsant response: a pilot study

Abstract Background The low carbohydrate, high fat ketogenic diet can be an effective anticonvulsant treatment in some pediatric patients with pharmacoresistant epilepsy. Its mechanism(s) of action, however, remain uncertain. Direct sampling of cerebrospinal fluid before and during metabolic therapy...

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Bibliographic Details
Main Authors: Susan A. Masino, David N. Ruskin, Natalie R. Freedgood, Marie Lindefeldt, Maria Dahlin
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Nutrition & Metabolism
Subjects:
Acetoacetate
Anticonvulsant
β-hydroxybutyrate
Cerebrospinal fluid
Glucose
Ketogenic diet
Online Access:https://doi.org/10.1186/s12986-020-00524-1

Internet

https://doi.org/10.1186/s12986-020-00524-1

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