Clusterin protects neurons against intracellular proteotoxicity

Clusterin protects neurons against intracellular proteotoxicity

Abstract It is now widely accepted in the field that the normally secreted chaperone clusterin is redirected to the cytosol during endoplasmic reticulum (ER) stress, although the physiological function(s) of this physical relocation remain unknown. We have examined in this study whether or not incre...

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Bibliographic Details
Main Authors: Jenna M. Gregory, Daniel R. Whiten, Rebecca A. Brown, Teresa P. Barros, Janet R. Kumita, Justin J. Yerbury, Sandeep Satapathy, Karina McDade, Colin Smith, Leila M. Luheshi, Christopher M. Dobson, Mark R. Wilson
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Acta Neuropathologica Communications
Subjects:
TDP-43
Cytoplasmic inclusions
Proteotoxicity
Chaperone translocation
Online Access:http://link.springer.com/article/10.1186/s40478-017-0481-1

Internet

http://link.springer.com/article/10.1186/s40478-017-0481-1

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