Preparation of the Key Dolutegravir Intermediate via MgBr<sub>2</sub>-Promoted Cyclization
A novel approach for synthesizing the key dolutegravir intermediate is described via MgBr<sub>2</sub>-promoted intramolecular cyclization. Condensation of commercially available methyl oxalyl chloride and ethyl 3-(<i>N</i>,<i>N</i>-dimethylamino)acrylate afforded...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/10/2850 |