Ciprofloxacin Affects Host Cells by Suppressing Expression of the Endogenous Antimicrobial Peptides Cathelicidins and Beta-Defensin-3 in Colon Epithelia

Ciprofloxacin Affects Host Cells by Suppressing Expression of the Endogenous Antimicrobial Peptides Cathelicidins and Beta-Defensin-3 in Colon Epithelia

Antibiotics exert several effects on host cells including regulation of immune components. Antimicrobial peptides (AMPs), e.g., cathelicidins and defensins display multiple functions in innate immunity. In colonic mucosa, cathelicidins are induced by butyrate, a bacterial fermentation product. Here,...

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Bibliographic Details
Main Authors: Protim Sarker, Akhirunnesa Mily, Abdullah Al Mamun, Shah Jalal, Peter Bergman, Rubhana Raqib, Gudmundur H. Gudmundsson, Birgitta Agerberth
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Antibiotics
Subjects:
antibiobic
microbiota
butyrate
histone modifications
host defense peptides
LL-37
innate immunity
impaired immune responses
Clostridium difficile
antibiotic-associated diarrhea
Online Access:http://www.mdpi.com/2079-6382/3/3/353

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http://www.mdpi.com/2079-6382/3/3/353

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