TIM4 Regulates the Anti-Islet Th2 Alloimmune Response

The role of the novel costimulatory molecule TIM4 in anti-islet response is unknown. We explored TIM4 expression and targeting in Th1 (BALB/c islets into C57BL/6 mice) and Th2 (BALB/c islets into Tbet -/- C57BL/6 mice) models of anti-islet alloimmune response and in a model of anti-islet autoimmune...

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Main Authors: Andrea Vergani, Francesca Gatti, Kang M. Lee, Francesca D'addio, Sara Tezza, Melissa Chin, Roberto Bassi, Ze Tian, Erxi Wu, Paola Maffi, Moufida Ben Nasr, James I. Kim, Antonio Secchi, James F. Markmann, David M. Rothstein, Laurence A. Turka, Mohamed H. Sayegh, Paolo Fiorina M.D., Ph.D
Format: Article
Language:English
Published: SAGE Publishing 2015-08-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368914X678571