DNA repair gene XRCC7 G6721T variant and susceptibility to colorectal cancer

Background: The human XRCC7 (MIM: 600899) is a DNA double-strand break repair gene, involved in non-homologous end joining (NHEJ). Polymorphism G6721T (rs7003908) is located in the intron 8 of the XRCC7. This polymorphism may regulate splicing and cause mRNA instability. Aim: The aim of the present...

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Bibliographic Details
Main Authors: Mostafa Saadat, Akram Rabizadeh-Hafshenjani
Format: Article
Language:English
Published: SpringerOpen 2016-10-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1110863016000239