Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ

Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ

Abstract Background The breast tumor microenvironment regulates progression of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC). However, it is unclear how interactions between breast epithelial and stromal cells can drive this progression and whether there are reliable microenviro...

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Bibliographic Details
Main Authors: Mansoureh Sameni, Dora Cavallo-Medved, Omar E. Franco, Anita Chalasani, Kyungmin Ji, Neha Aggarwal, Arulselvi Anbalagan, Xuequn Chen, Raymond R. Mattingly, Simon W. Hayward, Bonnie F. Sloane
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Breast Cancer Research
Subjects:
Ductal carcinoma in situ
Myoepithelial cells
Fibroblasts
Tumor microenvironment
Proteolysis
3D pathomimetic model
Online Access:http://link.springer.com/article/10.1186/s13058-017-0847-0

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http://link.springer.com/article/10.1186/s13058-017-0847-0

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