MVL-PLA2, a snake venom phospholipase A2, inhibits angiogenesis through an increase in microtubule dynamics and disorganization of focal adhesions.

MVL-PLA2, a snake venom phospholipase A2, inhibits angiogenesis through an increase in microtubule dynamics and disorganization of focal adhesions.

Integrins are essential protagonists of the complex multi-step process of angiogenesis that has now become a major target for the development of anticancer therapies. We recently reported and characterized that MVL-PLA2, a novel phospholipase A2 from Macrovipera lebetina venom, exhibited anti-integr...

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Main Authors: Amine Bazaa, Eddy Pasquier, Céline Defilles, Ines Limam, Raoudha Kessentini-Zouari, Olfa Kallech-Ziri, Assou El Battari, Diane Braguer, Mohamed El Ayeb, Naziha Marrakchi, José Luis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2853567?pdf=render

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http://europepmc.org/articles/PMC2853567?pdf=render

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