PLA2R binds to the annexin A2-S100A10 complex in human podocytes

Abstract Phospholipase A2 receptor (PLA2R) is a member of the mannose receptor family found in podocytes in human kidney. PLA2R is the target of the autoimmune disease, membranous nephropathy, characterised by production of anti-PLA2R autoantibodies which bind to the podocyte. However the function o...

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Bibliographic Details
Main Authors: Maryline Fresquet, Thomas A. Jowitt, Edward A. McKenzie, Matthew D. Ball, Michael J. Randles, Rachel Lennon, Paul E. Brenchley
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07028-8