Phosphoproteomics Reveals Regulatory T Cell-Mediated DEF6 Dephosphorylation That Affects Cytokine Expression in Human Conventional T Cells

Phosphoproteomics Reveals Regulatory T Cell-Mediated DEF6 Dephosphorylation That Affects Cytokine Expression in Human Conventional T Cells

Regulatory T cells (Tregs) control key events of immune tolerance, primarily by suppression of effector T cells. We previously revealed that Tregs rapidly suppress T cell receptor (TCR)-induced calcium store depletion in conventional CD4+CD25− T cells (Tcons) independently of IP3 levels, consequentl...

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Bibliographic Details
Main Authors: Rubin N. Joshi, Nadine A. Binai, Francesco Marabita, Zhenhua Sui, Amnon Altman, Albert J. R. Heck, Jesper Tegnér, Angelika Schmidt
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
regulatory T cell
Treg
CD4 T cell
phosphoproteomics
DEF6
SLAT
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01163/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01163/full

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