Dehydroxyhispolon Methyl Ether, A Hispolon Derivative, Inhibits WNT/β-Catenin Signaling to Elicit Human Colorectal Carcinoma Cell Apoptosis

Dehydroxyhispolon Methyl Ether, A Hispolon Derivative, Inhibits WNT/β-Catenin Signaling to Elicit Human Colorectal Carcinoma Cell Apoptosis

Colorectal cancer (CRC) is the fourth leading cause of cancer mortality worldwide. Aberrant activation of WNT/β-catenin signaling present in the vast majority of CRC cases is indispensable for CRC initiation and progression, and thus is a promising target for CRC therapeutics. Hispolon is a fungal-d...

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Bibliographic Details
Main Authors: Hueng-Chuen Fan, Ya-Chu Hsieh, Li-Hsuan Li, Ching-Chin Chang, Karolína Janoušková, Modukuri V. Ramani, Gottumukkala V. Subbaraju, Kur-Ta Cheng, Chia-Che Chang
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
dehydroxyhispolon methyl ether
hispolon
hispolon derivatives
<i>Phellinus linteus</i>
WNT/β-catenin
colorectal cancer
Online Access:https://www.mdpi.com/1422-0067/21/22/8839

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https://www.mdpi.com/1422-0067/21/22/8839

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