Inhibition of Glycolysis Suppresses Cell Proliferation and Tumor Progression In Vivo: Perspectives for Chronotherapy

Inhibition of Glycolysis Suppresses Cell Proliferation and Tumor Progression In Vivo: Perspectives for Chronotherapy

A high rate of glycolysis is considered a hallmark of tumor progression and is caused by overexpression of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3). Therefore, we analyzed the possibility of inhibiting tumor and endothelial cell metabolism through the inhibition of P...

Full description

Bibliographic Details
Main Authors: Jana Horváthová, Roman Moravčík, Miroslava Matúšková, Vladimír Šišovský, Andrej Boháč, Michal Zeman
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
glycolysis
PFKFB3
PFK15
cancer
chronotherapy
HUVEC
Online Access:https://www.mdpi.com/1422-0067/22/9/4390

Internet

https://www.mdpi.com/1422-0067/22/9/4390

Similar Items