Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

The SOX2 pioneer transcription factor performs critical roles in pluripotency and self-renewal of embryonic stem cells. Here the authors show that SOX2’s two nuclear localization signal sequences form a contiguous binding interface on the nuclear import receptor importin-α3, and provide a structural...

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Bibliographic Details
Main Authors: Bikshapathi Jagga, Megan Edwards, Miriam Pagin, Kylie M. Wagstaff, David Aragão, Noelia Roman, Jeffrey D. Nanson, Shane R. Raidal, Nicole Dominado, Murray Stewart, David A. Jans, Gary R. Hime, Silvia K. Nicolis, Christopher F. Basler, Jade K. Forwood
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20194-0

Internet

https://doi.org/10.1038/s41467-020-20194-0

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