Epigenetic Modification of Death Receptor Genes for TRAIL and TRAIL Resistance in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia

Epigenetic Modification of Death Receptor Genes for TRAIL and TRAIL Resistance in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia

Immunotherapies specific for B-cell precursor acute lymphoblastic leukemia (BCP-ALL), such as anti-CD19 chimeric antigen receptor (CAR) T-cells and blinatumomab, have dramatically improved the therapeutic outcome in refractory cases. In the anti-leukemic activity of those immunotherapies, TNF-relate...

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Bibliographic Details
Main Authors: Atsushi Watanabe, Kunio Miyake, Koshi Akahane, Kumiko Goi, Keiko Kagami, Hideo Yagita, Takeshi Inukai
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Genes
Subjects:
TNF-related apoptosis-inducing ligand
death receptors
epigenetics
B-cell precursor acute lymphoblastic leukemia
Online Access:https://www.mdpi.com/2073-4425/12/6/864

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https://www.mdpi.com/2073-4425/12/6/864

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