JAK inhibitors impair GM-CSF-mediated signaling in innate immune cells

JAK inhibitors impair GM-CSF-mediated signaling in innate immune cells

Abstract Background Innate immune cells play a crucial role in the pathophysiology of rheumatoid arthritis (RA) via release of cytokines. Small-molecule inhibitors of Janus kinases (JAKi) are clinically efficacious in patients with RA. However, the isoform-specific action of each JAKi is difficult t...

Full description

Bibliographic Details
Main Authors: Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Furuya-Yashiro, Tomoyuki Asano, Shuzo Sato, Haruki Matsumoto, Hiroshi Watanabe, Hideko Kozuru, Hiroshi Yatsuhashi, Atsushi Kawakami, Kiyoshi Migita
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Immunology
Subjects:
Baricitinib
GM-CSF
IL-1β
Janus kinases
Rheumatoid arthritis
Tofacitinib
Online Access:http://link.springer.com/article/10.1186/s12865-020-00365-w

Internet

http://link.springer.com/article/10.1186/s12865-020-00365-w

Similar Items