Synthesis and biological evaluation of novel quinoline analogs of ketoprofen as multidrug resistance protein 2 (MRP2) inhibitors

Objective(s): A new series of quinoline analogs of ketoprofen was designed and synthesized as multidrug resistance protein 2 (MRP2) inhibitors using ketoprofen as the lead compounds.Materials and Methods:  The cytotoxic activity of the compounds was evaluated againt two cancer cell lines including A...

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Bibliographic Details
Main Authors: Fatemeh Mosafa, Farzin Hadizadeh, Faezeh Fathi, Zahra Eslami Nasab, Tahereh Pourzahed, Sayyed Mohammad Aboutorabzade, Razieh Ghodsi
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2021-06-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Online Access:https://ijbms.mums.ac.ir/article_18109_8c5f07a9171bebfa78f574c2cf2eef15.pdf