The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: a subgroup analysis of the Sedation Practice in Intensive Care Evaluation [SPICE III] Trial

The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: a subgroup analysis of the Sedation Practice in Intensive Care Evaluation [SPICE III] Trial

Abstract Background Septic shock is associated with decreased vasopressor responsiveness. Experimental data suggest that central alpha2-agonists like dexmedetomidine (DEX) increase vasopressor responsiveness and reduce catecholamine requirements in septic shock. However, DEX may also cause hypotensi...

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Bibliographic Details
Main Authors: Luca Cioccari, Nora Luethi, Michael Bailey, Yahya Shehabi, Belinda Howe, Anna S. Messmer, Helena K. Proimos, Leah Peck, Helen Young, Glenn M. Eastwood, Tobias M. Merz, Jukka Takala, Stephan M. Jakob, Rinaldo Bellomo, for the ANZICS Clinical Trials Group and the SPICE III Investigators
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Critical Care
Subjects:
Sepsis
Septic shock
Sedation
Hemodynamics
Dexmedetomidine
Noradrenaline
Online Access:http://link.springer.com/article/10.1186/s13054-020-03115-x

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http://link.springer.com/article/10.1186/s13054-020-03115-x

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