Synthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis

Herein, we describe the syntheses of a complex biosynthesis-intermediate analogue of the potent antitumor polyketide borrelidin and of reference molecules to determine the stereoselectivity of the dehydratase of borrelidin polyketide synthase module 3. The target molecules were obtained from a commo...

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Bibliographic Details
Main Authors: Frank Hahn, Nadine Kandziora, Steffen Friedrich, Peter F. Leadlay
Format: Article
Language:English
Published: Beilstein-Institut 2014-03-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.10.55