Reversible induction of mitophagy by an optogenetic bimodular system

Reversible induction of mitophagy by an optogenetic bimodular system

Autophagic degradation of mitochondria (mitophagy) is a key quality control mechanism in cellular homeostasis, and its misregulation is involved in neurodegenerative diseases. Here the authors develop an optogenetic system for reversible induction of mitophagy and validate its use in cell culture an...

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Bibliographic Details
Main Authors: Pasquale D’Acunzo, Flavie Strappazzon, Ignazio Caruana, Giacomo Meneghetti, Anthea Di Rita, Luca Simula, Gerrit Weber, Francesca Del Bufalo, Luisa Dalla Valle, Silvia Campello, Franco Locatelli, Francesco Cecconi
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09487-1

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https://doi.org/10.1038/s41467-019-09487-1

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