A dual controllability analysis of influenza virus-host protein-protein interaction networks for antiviral drug target discovery

A dual controllability analysis of influenza virus-host protein-protein interaction networks for antiviral drug target discovery

Abstract Background Host factors of influenza virus replication are often found in key topological positions within protein-protein interaction networks. This work explores how protein states can be manipulated through controllability analysis: the determination of the minimum manipulation needed to...

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Bibliographic Details
Main Authors: Emily E. Ackerman, John F. Alcorn, Takeshi Hase, Jason E. Shoemaker
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Bioinformatics
Subjects:
Network analysis
Controllability
Systems biology
Virus-host interactions
Influenza virus
Online Access:http://link.springer.com/article/10.1186/s12859-019-2917-z

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http://link.springer.com/article/10.1186/s12859-019-2917-z

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