The rare nonsense mutation in p53 triggers alternative splicing to produce a protein capable of inducing apoptosis.

The rare nonsense mutation in p53 triggers alternative splicing to produce a protein capable of inducing apoptosis.

P53 protein is more frequently mutated in human tumours compared with the other proteins. While the majority of the p53 mutations, especially within its DNA-binding domain, lead to the loss of the wild-type function, there are accumulating data demonstrating that the p53 mutants gain tumour promotin...

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Bibliographic Details
Main Authors: Evgeny M Makarov, Tatyana A Shtam, Roman A Kovalev, Rimma A Pantina, Elena Yu Varfolomeeva, Michael V Filatov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5621691?pdf=render

Internet

http://europepmc.org/articles/PMC5621691?pdf=render

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