A surgical method for continuous intraportal infusion of gut microbial metabolites in mice

Gut microbe–derived metabolites influence human physiology and disease. However, establishing mechanistic links between gut microbial metabolites and disease pathogenesis in animal models remains challenging. The major route of absorption for microbe-derived small molecules is venous drainage via th...

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Bibliographic Details
Main Authors: Danny Orabi, Lucas J. Osborn, Kevin Fung, William Massey, Anthony J. Horak III, Federico Aucejo, Ibrahim Choucair, Beckey DeLucia, Zeneng Wang, Jan Claesen, J. Mark Brown
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-05-01
Series:JCI Insight
Subjects:
Online Access:https://doi.org/10.1172/jci.insight.145607